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药学(336)

姓名:李**

性别:男

国籍:韩国

联系电话:0631-5651499

E-Mail:xinhanrc@163.com

教育经历

1979.03.02- 1983.02.28 毕业于首尔大学工业化学系(工学系)
1983.03.02 - 1985.02.28 韩国科学技术院(KAIST)化学系毕业(理学硕士)
1987.03.02-1992.02.28 韩国科学技术院(KAIST)化学系毕业(理学博士)
 

研究方向

发掘抗癌剂、抗炎剂等新药候选物质
 
• 医药品及医药品中间体合成工艺改善研究
 
• 开发新的有机合成法
 
• 药品标准品制造
 

主要成果

210. H. J. Kim, B. K. Jang, J.-H. Park, J. W. Choi, S. J. Park, S. R. Byeon, A. N. Pae, Yong Sup Lee, E. Cheong, Ki Duk Park* A novel chalcone derivative as Nrf2 activator attenuates learning and memory impairment in a scopolamine-induced mouse model, European Journal of Medicinal Chemistry, 2020, 185, 111777.
 
211. A. Abiero, I. S. Ryu, C. J. Botanas, R. J. P. Custodio, L. V. Sayson, M. Kim, H. J. Lee, H. J. Kim, J.-W. Seo, M. C. Cho, K. W. Lee, S. Y. Yoo, C.-G. Jang, Yong Sup Lee* and Jae Hoon Cheong* Four Novel Synthetic Tryptamine Analogs Induce Head-Twitch Responses and Increase 5-HTR2a in the Prefrontal Cortex in Mice, Biomolecules & Therapeutics, 2020, 28, 83-91.
 
212. A.H.E. Hassan, K.-T.e Lee, Yong Sup Lee* Flavone-based arylamides as potential anticancers: Design, synthesis and in vitro cell-based/cell-free evaluations, European Journal of Medicinal Chemistry, 2020, 187, 111965.
 
213. A. Abiero, C. J. Botanas, R. J. Custodio, L. V. Sayson, M. Kim, H. J. Lee, H. J. Kim, K. W. Lee, Y. Jeong, J.-W. Seo, I. S. Ryu, Yong Sup Lee* & Jae Hoon Cheong* 4-MeO-PCP and 3-MeO-PCMo, new dissociative drugs, produce rewarding and reinforcing effects through activation of mesolimbic dopamine pathway and alteration of accumbal CREB, deltaFosB, and BDNF levels, Psychopharmacology 2020, 237, 757-772.
 
214. A.H.E. Hassan, K. T. Park, H. J. Kim, H. J. Lee, Y. H. Kwon, J. Y. Hwang, C.-G. Jang, J. H. Chung, K. D. Park, S. J. Lee, Seung Jun Oh*, Yong Sup Lee* Fluorinated CRA13 analogues: Synthesis, in vitro evaluation, radiosynthesis, in silico and in vivo PET study, Bioorganic Chemistry 2020, 99, 103834.
 
SCI级学术刊物发表论文(截至2021年共发表约234篇)