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药学(333)

姓名:金**

性别:男

国籍:韩国

联系电话:0631-5651499

E-Mail:xinhanrc@163.com

教育经历

1977-1981年:韩国忠北大学药学院学士
1981-1983年: 韩国首尔大学药学院硕士
1984-1988年:美国休斯敦大学生物化学和生物物理系博士
 

研究方向

炎症反应的信号转导及其调控集中在NF-kB和STAT途径。
IL-5、IL-3、GM-CSF等Th2细胞因子的抗过敏反应及作用机制
色素紊乱生化调控网络研究cAMP诱导黑色素生物合成
 

主要成果

代表论文
 
Yun C-Y, Ko SM, Choi YP, Kim BJ, Lee JR, Kim JM, Kim JY, Song JY, Kim SH, Hwang BY, Hong JT, Han S-B, Kim Y. Alpha-viniferin improves facial hyperpigmentation via accelerating feedback termination of cAMP/PKA-signaled phosphorylation circuit in facultative melanogenesis. Theranosctics 9: 2031-2043 (2018)
 
Park SH, Kwak JA, Jung SH, Ahn B, Cho WJ, Yun C-Y, Na CS, Hwang BY, Hong JT, Han S-B, Kim Y. Piperidylmethyloxychalcone improves immune-mediated acute liver failure via inhibiting TAK1 activity. Exp. Mol. Med. 49: e392 (2017)
 
Boggu PR, Venkateswararao E, Manickam M, Kim Y, Jung SH. Discovery of novel 3-(hydroxyalkoxy)-2-alkylchromone-4-one analogs as interleukin-5 inhibitors. Eur. J. Med. Chem. 139: 290-304 (2017)
 
Choi JH, Park SH, Jung JK, Cho WJ, Ahn B, Yun C-Y, Yeo JW, Lee H, Hong JT, Han S-B, Kim Y. Caffeic acid cyclohexylamide rescues lethal inflammation in septic mice through inhibition of IkB kinase in innate immune process. Sci. Rep. 7: 41180 (2017)
 
Boggu PR, Venkateswararao E, Manickam M, Kwak DJ, Kim Y, Jung SH. Exploration of 2-benzylbenzimidazole scaffold as novel inhibitor of NF-kB. Bioorg. Med. Chem. 24: 1872-1878 (2016)
 
Shin H, Hong SD, Roh E, Jung SH, Cho WJ, Park SH, Yoon DY, Ko SM, Hwang BY, Hong JT, Heo T-Y, Han S-B, Kim Y. cAMP-dependent activation of protein kinase A as a therapeutic target of skin hyperpigmentation by diphenylmethylene hydrazinecarbothioamide. Br. J. Pharmacol. 172: 3434-3445 (2015)
 
Park SH, Baek S-I, Yun J, Lee S, Yoon DY, Jung JK, Jung SH, Hwang BY, Hong JT, Han S-B, Kim Y. IRAK4 as a molecular target in the amelioration of innate immunity-related endotoxic shock and acute liver injury by chlorogenic acid. J. Immunol. 194: 1122-1130 (2015)
 
Roh E, Jeong I-Y, Shin H, Song S, Hong JT, Lee S, Han S-B, Kim Y. Downregulation of melanocyte-specific facultative melanogenesis by 4-hydroxy-3-methoxycinnamaldehyde acting as a cAMP antagonist. J. Invest. Dermatol. 134: 551-553 (2014)
 
Park SH, Roh E, Kim HS, Baek S-I, Choi NS, Kim N, Hwang BY, Han S-B, Kim Y. Inhibition of IRAK-4 activity for rescuring endotoxin LPS-induced septic mortality in mice by lonicerae flos extract. Biochem. Biophys. Res. Commun. 442: 183-184 (2013)
 
Roh E, Yun C-Y, Yun JY, Park D, Kim ND, Hwang BY, Jung SH, Park SK, Kim Y-B, Han S-B, Kim Y. cAMP-binding site of PKA as a molecular target of bisabolangelone against melanocyte-specific hyperpigmented disorder. J. Invest. Dermatol. 133: 1072-1079 (2013)